🧩 Inventive Mechanisms 02: Scaling Science, Usability, and Scraping
Macrocosmos x Rowan Scientific. A partnership to advance molecular simulations on SN25 and scale AI-assisted drug discovery.
Editors take: With every new subnet upgrade, integration, and research collaboration, Macrocosmos is proving itself as the backbone of decentralized AI infrastructure.
TL;DR: This week’s roundup features updates across SN25, SN13, SN9, SN37, and SN1 — including a major partnership with Rowan Scientific, live YouTube scraping, a fresh SDK release, and new dev tools now in the Cosmos.
This week in Subnets
SN25: Partnering with Rowan Scientific
Macrocosmos is teaming up with Rowan Scientific, an AI-native chemistry software company, to expand what's possible with molecular simulations on SN25 (Mainframe). This collaboration enables Rowan to access high-quality Density Functional Theory (DFT) configurations—essential components in the training of next-generation simulation models.
By dynamically generating training data on SN25, Rowan can scale the speed and precision of their drug discovery tools. This isn’t just a partnership; it’s a glimpse into how decentralized science (DeSci) can push research forward.
👉 Explore SN25’s capabilities in the API Docs
👉 Try SN25’s beta in Constellation
SN13: YouTube Scraping Goes Live
Data Universe has a new data source—YouTube! Using SN13 , you can now scrape:
Full video transcripts
Metadata (title, channel, language, duration)
Descriptions
Over 26,000 videos (7,000+ hours of content) have already been processed in under 3 days.
👉 Browse the repo on Hugging Face , and stay tuned for tutorials on our docs.
SN9: Competition Update
TTS shows signs of overfitting. Work is underway to reduce denoising steps and increase sampling to stabilize variance and vTrust scores.
Miners on SN9 should prepare for upcoming changes.
SN37: Hotfix v3.0.5 Released
Thanks to @PawKanarek on Discord for identifying a key bug. This hotfix includes:
Fixed dataloader bug in the Codeforces dataset
Increased validation sample size by 50% to reduce variance
🔧 Validators: Please update your setup with:
ulimit -n 64000
python -m pip install -e .
SN1: New Validator Endpoints in Progress
The SN1 team is developing new endpoints for the upcoming Deep Researcher feature. More to come soon.
Additionally, SN13’s on-demand data request endpoint will be accessible via Constellation, thanks to backend improvements like load balancing.
April Subnet Status Report
Catch the full April subnet recap, including our presence at the Endgame, product updates, and roadmap notes.
👉 View Update Thread
Tools & Dev Updates
Macrocosmos SDK v1.0.0 Released
A stable SDK release is now live. If you're building with the Macrocosmos SDK:
Re-login to Constellation
Request new auth & credits via Discord or Telegram
👉 View Release Notes
👉 Read SDK Docs
Mainframe Docs + Beta Access
SN25 (Mainframe) API docs are now live
Beta access is available through Constellation
👉 View Docs
👉 Try Mainframe
SN1 Base Miner
Want to build or test mining on SN1, Apex? We’ve just published the SN1 Base Miner documentation, making it easier than ever to get started.
👉 View Docs
In other news:
Student-Built App on SN1
Students at Purdue University have built Tone Match, an emotion-aware text transformation tool powered by SN1, Apex.
👉 Check out the demo → Tone Match
Developer Call-Out
Want to contribute to subnet powered projects and tools? Reach out on Telegram. We’re always looking for builders.
Events
We’re thrilled to announce that Will Squires, Co-Founder & CEO of will be speaking at Proof of Talk 2025, joining 120+ leading voices at the forefront of Web3 and AI.
👉 Click to learn more here
Clickworthy things
Thanks for reading Issue 02 of Inventive Mechanisms.
See you next week!